Do short rests between sets level down the muscle growth rate? In essence, resting less than one minute between sets is more popular in bodybuilding exercises because it exerts more tension on muscles and is recommended due to the increase in blood anabolic hormones release (for instance, testosterone) compared to long rests between sets. However, hormonal reaction immediately after powerlifting exercise has nothing to do with muscle growth (it is insignificant and short-term). Therefore, it is more appropriate to ask “are short rests between sets beneficial for muscle growth or have negative points? A study has been conducted on this matter by comparing the effect of 1-minute and 5-minute resting between sets on muscle protein synthesis (muscle adaptation process). This research was carried out on trained men (powerlifting exercise) and all subjects did 4 workout sets with 75% of their maximum power and one rep for each movement of leg press and leg stretch. It is not surprising that 1-minute rest protocol led to the 13% decrease in exercise level. In conclusion, the 1-minute rest protocol leads to a 37% decrease in muscle protein synthesis level compared to 5-minute rest. Of course, short rest between sets is more efficient for exercise timing, and we chose 5-minute rest in our study to illustrate the difference better, and maybe 2 minutes is the most effective time to rest between sets. Moreover, you can follow super-set workout programs for better progress and severer muscle pressure. This approach helps to provide you with more time and adequate rest during exercises.